Esophageal Applicator (E-APP)™
The E-APP™ is a first of its kind, disposable brachytherapy applicator designed specifically for the treatment of upper GI cancers. Five independently operable balloons are designed to maintain the central position of the source catheter in both straight and curved anatomy allowing for closer proximity of the target to the source while maintaining distance for healthy tissue.
Ancer Medical, E-App™ Clinical Case Study
The patient, a 71 year old female was found to have a low lying rectal cancer initially treated with chemotherapy but was not a candidate for pelvic radiotherapy due to previous radiotherapy for cervical cancer in the 1970’s. As an alternative to an abdominoperineal resection, endoluminal high-dose brachytherapy was chosen.
Purpose: In this study, we present the clinical implementation of a novel transoral balloon centering esophageal applicator (BCEA) and the initial clinical experience in high-dose-rate (HDR) brachytherapy treatment of esophageal cancer, using this applicator.
Clinical Use of a Novel Balloon Based Esophageal Brachytherapy Applicator
Purpose: High dose rate endoesophageal brachytheropy is an option in the management of primary and recurrent esophageal cancer in inoperable patients. In review of a series of patients treated at our institute (Folkert et al Brachytheropy 2013) we found HDR brachytheropy was safe and well tolerated, but was associated with a high rate of local recurrence. To overcome the limitation of surface dose and enable a dose escalation study we designed a novel balloon based applicator (Cohen and Goodman, Brachytheropy 2015). Here we report on the initial clinical use of this applicator.
Initial Experience in High-dose-rate Brachytherapy Treatment of the Esophagus Using a Novel Esophageal Applicator
Purpose: The purpose of the study is to report the initial experience in the treatment of locally advanced esophageal carcinoma with high-dose-rate (HDR) brachytherapy using a novel transoral balloon centering esophageal applicator (E-APP, Ancer Medical).tor.